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A comparative study of resting state functional connectivity MRI and intracranial EEG for epilepsy surgery

Research Project

Project/Area Number 26462216
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionWakayama Medical University

Principal Investigator

Nishibayashi Hiroki  和歌山県立医科大学, 医学部, 講師 (30372866)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywordsてんかん / 機能的MRI / 機能的結合 / 頭蓋内脳波 / 発作焦点 / functional connectivity / 安静時機能的MRI / 難治化 / てんかん原性領域 / 脳機能再構築 / 安静時機能的MRI / 発作型
Outline of Final Research Achievements

Resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) were applied for pre-surgical evaluation of patients who underwent resective surgery via intracranial EEG. Reduced network centrality was prominent in ictal onset zones by voxel-to-voxel analysis. Sequential alteration of functional connectivity was analyzed by selecting remnant epileptic focus as a region of interest using seed-to voxel analysis. Imaging findings of rs-fcMRI altered according to clinic-encephalographic state. Rs-fcMRI is a useful tool even for an individual epileptic patient to explore epileptic focus and estimate clinical condition.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] てんかん患者の脳内ネットワーク構造変化2015

    • Author(s)
      中井康雄、金桶吉起、西林宏起、堂西倫弘、寺田正樹、小倉光博、中尾直之
    • Journal Title

      第30回日本生体磁気学会大会論文集

      Volume: 28 Pages: 148-149

    • Related Report
      2015 Research-status Report
  • [Journal Article] 発作型による辺縁系の安静時機能的結合MRI所見の相違2014

    • Author(s)
      西林宏起 中尾直之
    • Journal Title

      CI研究

      Volume: 36(1) Pages: 23-27

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 安静時機能的MRIの解析で得られるHubのてんかん原性領域における局在2016

    • Author(s)
      西林宏起、小倉光博、中尾直之
    • Organizer
      第75回日本脳神経外科学会総会
    • Place of Presentation
      福岡市
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] てんかん焦点切除周辺の安静時機能的MRI所見の術後変化2016

    • Author(s)
      西林宏起、小倉光博、尾崎充宣、中尾直之
    • Organizer
      第39回日本てんかん外科学会
    • Place of Presentation
      仙台市
    • Year and Date
      2016-01-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 側頭葉てんかんの難治性による安静時機能的MRI所見の相違2015

    • Author(s)
      西林宏起、中井康雄、小倉光博、中尾直之
    • Organizer
      第49回日本てんかん学会学術集会
    • Place of Presentation
      長崎市
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
  • [Presentation] てんかん焦点切除周辺皮質の安静時機能的MRI所見の術後変化2015

    • Author(s)
      西林宏起、小倉光博、中尾直之
    • Organizer
      第74回日本脳神経外科学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2015-10-14
    • Related Report
      2015 Research-status Report
  • [Presentation] てんかん患者の脳内ネットワーク変化2015

    • Author(s)
      中井康雄、金桶吉起、西林宏起、堂西倫弘、寺田正樹、小倉光博、中尾直之
    • Organizer
      第30回日本生体磁気学会大会
    • Place of Presentation
      旭川市
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 発作起始部位を関心領域とした安静時機能的結合MRI所見2014

    • Author(s)
      西林宏起 小倉光博 中尾直之
    • Organizer
      第73回 日本脳神経外科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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