| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We developed a rat model of bladder underactivity induced by chronic bladder ischemia. A prominent finding in this model is that bladder overactivity was observed in the relatively early period, whereas bladder underactivity was found in the late period. Chronic bladder ischemia and repeated ischemia / reperfusion produce oxidative stress in the bladder, leading to denervation of the bladder and expression of tissue damaging molecules in the bladder wall. This may contribute to the development of bladder overactivity progressing to bladder underactivity. Our findings suggest that prolonged bladder ischemia may cause bladder dysfunction, which develops from bladder overactivity to bladder underactivity.
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