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Clarification of the threshold value of micromotion and the appropriate timing of starting of load to acquire osseointegration of immediate and early loaded implants

Research Project

Project/Area Number 26462973
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionNara Medical University

Principal Investigator

Kazuhiro Murakami  奈良県立医科大学, 医学部附属病院, 研究員 (60569078)

Co-Investigator(Kenkyū-buntansha) 山本 一彦  奈良県立医科大学, 医学部, 准教授 (20243842)
石田 純一  奈良県立医科大学, 医学部, 研究員 (40724638)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords歯科インプラント / 微小動揺 / 即時・早期荷重 / オッセオインテグレーション / 機能的動的荷重 / 骨形態計測 / レーザー変位計 / 動的荷重 / 最適荷重開始時期 / 共鳴振動周波数 / 有限要素解析 / インプラント安定度 / 即時、早期荷重
Outline of Final Research Achievements

The micromotion (MM)of immediately loaded dental implants placed in the tibia of rabbits was monitored by a laser displacement sensor. The condition of the bone around the implants was histomorphometrically analyzed. The osteointegration of the implant could not be obtained in early loading even if a low loading value was applied, but the osseointegration could be obtained in delayed loading even if a high load value was applied. The initial loosening was not developed by loading at 5 days after implantation. In histomorphometrically analysis, bone contact rate showed the maximal value at 5 days after implantation and bone volume around implant showed the maximal value at immediate loading. From these results, the bone volume around implant can increase in the early loading, but the possibility of implant’s lost is increased. By setting a healing period for a while, the bone contacted rate increases, and the success rate also increases.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (22 results)

All 2018 2017 2016 2015 2014

All Journal Article (14 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 13 results,  Open Access: 14 results,  Acknowledgement Compliant: 2 results) Presentation (8 results)

  • [Journal Article] Micromotion analysis of different implant configuration, bone density, and crestal cortical bone thickness in immediately loaded mandibular full-arch implant restorations: A nonlinear finite element study.2018

    • Author(s)
      Sugiura T, Yamamoto K, Horita S, Murakami K, Kirita T.
    • Journal Title

      Clin Implant Dent Relat Res

      Volume: 20 Issue: 1 Pages: 43-49

    • DOI

      10.1111/cid.12573

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spindle Cell Hemangioma in the Mucosa of the Upper Lip: A Case Report and Review of the Literature2018

    • Author(s)
      Murakami Kazuhiro、Yamamoto Kazuhiko、Sugiura Tsutomu、Kirita Tadaaki
    • Journal Title

      Case Reports in Dentistry

      Volume: 2018 Pages: 1-7

    • DOI

      10.1155/2018/1370701

    • Related Report
      2017 Annual Research Report
    • Open Access
  • [Journal Article] Computed Tomography-Based 3-Dimensional Finite Element Analyses of Various Types of Plates Placed for a Virtually Reduced Unilateral Condylar Fracture of the Mandible of a Patient.2017

    • Author(s)
      Murakami K, Yamamoto K, Sugiura T, Horita S, Matsusue Y, Kirita T.
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 24 Issue: 6 Pages: 30223-9

    • DOI

      10.1016/j.joms.2017.02.014

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biomechanical analysis of immediately loaded implants according to the “All-on-Four” concept2017

    • Author(s)
      Horita S, Sugiura T, Yamamoto K, Murakami K, ImaiY, Kirita T.
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 61 Issue: 2 Pages: 123-132

    • DOI

      10.1016/j.jpor.2016.08.002

    • NAID

      130005628590

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Chronic maxillary sinusitis caused by denture lining material.2016

    • Author(s)
      Sugiura T, Yamamoto K, Nakashima C, Murakami K, Matsusue Y, Horita S, Sakagami G, Kirita T
    • Journal Title

      Open Dent J

      Volume: 10 Issue: 1 Pages: 261-267

    • DOI

      10.2174/1874210601610010261

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The effects of bone density and crestal cortical bone thickness on micromotion and peri-implant bone strain distribution in an immediately loaded implant: a nonlinear finite element analysis.2016

    • Author(s)
      Sugiura T, Yamamoto K, Horita S, Murakami K, Tsutsumi S, Kirita T.
    • Journal Title

      J Periodontal Implant Sci

      Volume: 46 Issue: 3 Pages: 152-65

    • DOI

      10.5051/jpis.2016.46.3.152

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Trend and Characteristics of 2,636 Maxillofacial Fracture Cases over 32 Years in Suburban City of Japan2015

    • Author(s)
      Yamamoto K, Matsusue Y, Horita S, Murakami K, Sugiura T, Kirita T.
    • Journal Title

      Craniomaxillofac Trauma Reconstr

      Volume: 8(4) Issue: 4 Pages: 281-288

    • DOI

      10.1055/s-0034-1399797

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Routine removal of the plate after surgical treatment for mandibular angle fracture with a third molar in relation to the fracture line.2015

    • Author(s)
      Yamamoto K, Matsusue Y, Horita S, Murakami K, Sugiura T, Kirita T.
    • Journal Title

      Ann Maxillofac Surg

      Volume: 5(1) Issue: 1 Pages: 77-81

    • DOI

      10.4103/2231-0746.161077

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of bone parameters on peri-implant bone strain distribution in the posterior mandible.2015

    • Author(s)
      Sugiura T, Yamamoto K, Kawakami M, Horita S, Murakami K, Kirita T.
    • Journal Title

      Med Oral Patol Oral Cir Bucal

      Volume: 20(1)

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biomechanical analysis of poly-L-lactic acid and titanium plates fixated for mandibular symphyseal fracture with a conservatively treated unilateral condylar fracture using the three-dimensional finite element method2015

    • Author(s)
      Murakami K, Yamamoto K, Sugiura T, Horita S, Kawakami M, Kirita T
    • Journal Title

      Dental traumatology

      Volume: 不明 Issue: 5 Pages: 396-402

    • DOI

      10.1111/edt.12179

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of bone parameters on peri-implant bone strain distribution in the posterior mandible2015

    • Author(s)
      Sugiura T, Yamamoto K, Kawakami M, Horita S, Murakami K, Kirita T
    • Journal Title

      Med Oral Patol Oral Cir Bucal

      Volume: 20 Pages: e66-e73

    • DOI

      10.4317/medoral.19878

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Theoretical Efficacy of Preventive Mesures for Pathologic Fracture After Surgical Removal of Mandibular lesions Based on a Three-Dimensional Finite Element Analysis2014

    • Author(s)
      Murakami K, Yamamoto K, Tsuyuki M, Sugiura T, Tsutsumi S, Kirita T
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 72

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 片側関節突起骨折を併発した下顎骨正中骨折におけるPLLAプレート固定の力学解析2014

    • Author(s)
      村上和宏、山本一彦、杉浦勉、川上正良、堀田聡、露木基勝、石田純一、堤定美、桐田忠昭
    • Journal Title

      臨床バイオメカニクス

      Volume: 35 Pages: 83-90

    • NAID

      40020255637

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 広範な顔面皮膚剥脱損傷を伴った顎顔面多発骨折の1例2014

    • Author(s)
      山本 一彦, 松末 友美子, 堀田 聡, 柳生 貴裕, 上田 順宏, 稲掛 耕太郎, 村上 和宏, 杉浦 勉, 桐田 忠昭
    • Journal Title

      日本顎顔面外傷

      Volume: 13 Pages: 6-12

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] インプラント周囲炎が誘因と考えられた下顎骨骨折の1例2017

    • Author(s)
      中上 佳寿彦, 堀田 聡, 山本 一彦, 杉浦 勉, 村上 和宏, 桐田 忠昭
    • Organizer
      Japanese Journal of Maxillo Facial Implants
    • Related Report
      2017 Annual Research Report
  • [Presentation] 自殺企図による顎顔面骨骨折20例についての臨床的検討2017

    • Author(s)
      中上 佳寿彦, 堀田 聡, 山本 一彦, 下辻 寛子, 山本 育久美, 松末 友美子, 村上 和宏, 杉浦 勉, 桐田 忠昭
    • Organizer
      障害者歯科
    • Related Report
      2017 Annual Research Report
  • [Presentation] 傾斜埋入および荷重方向が即時荷重インプラントの微小動揺に及ぼす影響2017

    • Author(s)
      杉浦 勉, 堀田 聡, 村上 和宏, 桐田 忠昭
    • Organizer
      日本口腔インプラント学会学術大会抄録集
    • Related Report
      2017 Annual Research Report
  • [Presentation] 下顎骨関節突起骨折に対するhigh submandibular transmasseteric anteroparotid approachによる観血的整復固定2017

    • Author(s)
      山本 一彦, 堀田 聡, 松末 友美子, 村上 和宏, 杉浦 勉, 桐田 忠昭
    • Organizer
      口腔顎顔面外傷
    • Related Report
      2017 Annual Research Report
  • [Presentation] 自殺企図による顎顔面骨骨折20例についての臨床的検討2017

    • Author(s)
      中上 佳寿彦, 山本 一彦, 堀田 聡, 松末 友美子, 村上 和宏, 杉浦 勉, 桐田 忠昭
    • Organizer
      日本口腔科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 欠損を伴った下唇裂傷後の醜形に対し複数回の修正術を施行した1例2017

    • Author(s)
      松末 友美子, 山本 一彦, 柳生 貴裕, 上山 善弘, 堀田 聡, 村上 和宏, 杉浦 勉, 桐田 忠昭
    • Organizer
      口腔顎顔面外傷
    • Related Report
      2017 Annual Research Report
  • [Presentation] 片側性関節突起骨折患者のCTに基づく有限要素モデルを用いたプレートと固定法の評価2016

    • Author(s)
      村上 和宏、山本 一彦、杉浦 勉、堀田 聡、松末友美子、露木基勝、石田純一、桐田 忠昭
    • Organizer
      第61回日本口腔外科学会総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 3次元有限要素モデル解析による下顎骨内病変摘出後の病的骨折の予測とその予防法および術後下顎骨の強度の回復についての検討2015

    • Author(s)
      村上和宏、露木基勝、石田純一、山本一彦、杉浦 勉、堀田 聡、川上正良、今井 裕一郎、上田 順宏、桐田 忠昭
    • Organizer
      日本口腔腫瘍学会総会
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2015-01-29 – 2015-01-30
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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