Modulatory effect of fluvastatin upon immune suppression regulated by mesenchymal stromal cells and oral squamous cell carcinoma cells
| Project/Area Number |
26463055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
Kondoh Nobuo 朝日大学, 歯学部, 教授 (40202072)
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| Co-Investigator(Kenkyū-buntansha) |
村松 泰徳 朝日大学, 歯学部, 教授 (30247556)
藤内 祝 横浜市立大学, 医学研究科, 教授 (50172127)
式守 道夫 朝日大学, 歯学部, 教授 (70154193)
光藤 健司 横浜市立大学, 医学部, 准教授 (70303641)
川木 晴美 朝日大学, 歯学部, 講師 (70513670)
高山 英次 朝日大学, 歯学部, 准教授 (70533446)
神谷 真子 朝日大学, 経営学部, 准教授 (80181907)
山崎 裕 北海道大学, 歯学研究科, 教授 (90250464)
本橋 征之 朝日大学, 歯学部, 准教授 (80396390)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔扁平上皮癌 / 間葉系間質細胞 / 免疫抑制 / fluvastatin / OSCC / IL1a / PMN-MDSC / IFN-gamma / 脾細胞 / IFN-γ / 間葉系間質細 / ＩＬ-10 |
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| Outline of Final Research Achievements |
We have established sub-clones from primary and metastasized oral squamous cell carcinoma (OSCC) from primary and metastasized tumors of tumor-implanted mice. IFN-gamma-producing capability of antigen-stimulated spleen cells from all of the tumor-implanted mice was significantly lower than that of control mice. IL-10-producing capability of spleen cells from tumor-bearing mice implanted with metastasized sub-clones was reduced, while that of the spleen cells from the mice implanted with non-metastasized sub-clones was increased. Polymorpho nuclear (PMN)- myeloid derived suppresser cells (MDSCs) were significantly increased in mice implanted with metastasized sub-clones. Our results demonstrate that OSCCs exert differential effects on the immune regulatory mechanisms, depending on their malignancy, i.e., metastatic potential.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Gene expression analyses associated with malignant phenotypes of metastatic subclones derived from a mouse oral squamous cell carcinoma cell line, Sq-1979.2017
Author(s)
Adach M, Mizuno-Kamiya M, Takayama E, Kawaki H, Inagaki T, Sumi S, Motohashi M, Muramatsu Y, Sumitomo S, Shikimori M, Yamazaki Y, Kondoh N
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Journal Title
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Tumor growth limited to a single site vs tumor growth in multiple sites exhibit differential effects on systemic immunities.2017
Author(s)
Masuda J, Takayama E, Strober W, Satoh A, Morimoto Y, Honjo Y, Ichinose T, Tokuno S, Ishizuka T, Nakata T, Mizutani A, Umemura N, Kitani A, Fuss IJ, Shigehiro T, Kawaki H, Mizuno-Kamiya M, Kondoh N, Seno M.
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Journal Title
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Promotion of Nickel (Ni) Allergy by Anamnestic Sensitization with a Bacterial Component, Lipopolysaccharide (LPS), in Mice.2016
Author(s)
Adachi N, Takayama E, Adachi M, Mizuno-Kamiya M, Kawaki H, Takeuchi H, Kubo S, Ishigami H, Kurachi M, Kondoh N.
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Journal Title
The Open Dentistry Journal
Volume: 10
Pages: 531-537
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients.2015
Author(s)
Iida M, Takayama E, Naganawa K, Mitsudo K, Adachi M, Baba J, Fujimoto-Muto M, Motohashi M, Mizuno-Kamiya M, Kawaki H, Kioi M, Ichinose M, Sumitomo S, Muramatsu Y, Shikimori M, Tohnai I, Kondoh N.
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Journal Title
The Open Dentistry Journal
Volume: 9
Pages: 120-124
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Increase of Peripheral Blood CD57+ T-Cells in Patients with Oral Squamous Cell Carcinoma.2014
Author(s)
Iida M, Takayama E, Naganawa K, Mitsudo K, Adachi M, Baba J, Fujimoto-Muto M, Motohashi M, Mizuno-Kamiya M, Kawaki H, Kioi M, Ichinose M, Sumitomo S, Muramatsu Y, Shikimori M, Tohnai I, Kondoh N.
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Journal Title
Anticancer Res.
Volume: 34
Pages: 5729-5734
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 幹細胞を組み合わせた骨再生療法2014
Author(s)
田中雅士, 川木晴美, 小栗健策, 森 春菜, 河野 哲, 近藤信夫, 吉田隆一
Organizer
第10回日本歯内療法学会 中部支部会
Place of Presentation
名古屋
Year and Date
2014-09-28
Related Report
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