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2016 Fiscal Year Final Research Report

Modulatory effect of fluvastatin upon immune suppression regulated by mesenchymal stromal cells and oral squamous cell carcinoma cells

Research Project

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Project/Area Number 26463055
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionAsahi University

Principal Investigator

Kondoh Nobuo  朝日大学, 歯学部, 教授 (40202072)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords口腔扁平上皮癌 / 間葉系間質細胞 / 免疫抑制 / fluvastatin
Outline of Final Research Achievements

We have established sub-clones from primary and metastasized oral squamous cell carcinoma (OSCC) from primary and metastasized tumors of tumor-implanted mice. IFN-gamma-producing capability of antigen-stimulated spleen cells from all of the tumor-implanted mice was significantly lower than that of control mice. IL-10-producing capability of spleen cells from tumor-bearing mice implanted with metastasized sub-clones was reduced, while that of the spleen cells from the mice implanted with non-metastasized sub-clones was increased. Polymorpho nuclear (PMN)- myeloid derived suppresser cells (MDSCs) were significantly increased in mice implanted with metastasized sub-clones. Our results demonstrate that OSCCs exert differential effects on the immune regulatory mechanisms, depending on their malignancy, i.e., metastatic potential.

Free Research Field

医歯薬学

URL: 

Published: 2018-03-22  

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