Epigenetic dysregulation of homeobox genes in radiation-induced rat mammary carcinogenesis

• Project/Area Number: 26740022
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Daino Kazuhiro 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 主任研究員(定常) (90543299)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 放射線 / 乳がん / エピジェネティクス / 発がん / 発生

Outline of Final Research Achievements

The mammary gland is one of the most sensitive organs to radiation carcinogenesis. However, epigenetic dysregulation in radiation-induced breast cancer have yet to be well characterized. In this study, we obtaiined results suggesting the involvement of epigenetic dysregulation of homeobox genes in radiation-induced rat mamamry carcinogenesis. In addition, we identified mutations in several epigenetic regulator genes in radiation-induced rat mammary carcinomas.

Research Products

• [Journal Article] Epigenetic dysregulation of key developmental genes in radiation-induced rat mammary carcinomas (2018)
  • Author(s): Daino Kazuhiro, Nishimura Mayumi, Imaoka Tatsuhiko, Takabatake Masaru, Morioka Takamitsu, Nishimura Yukiko, Shimada Yoshiya, Kakinuma Shizuko
  • Journal Title: Int J Cancer Volume: - Issue: 2 Pages: 000-000
  • DOI: 10.1002/ijc.31309
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas (2016)
  • Author(s): Kaye Showler , Mayumi Nishimura , Kazuhiro Daino , Tatsuhiko Imaoka , Yukiko Nishimura , Takamitsu Morioka , Benjamin J. Blyth , Toshiaki Kokubo , Masaru Takabatake , Maki Fukuda , Hitomi Moriyama , Shizuko Kakinuma , Masahiro Fukushi , Yoshiya Shimada
  • Journal Title: Journal of radiation research Volume: 58 Issue: 2 Pages: 183-194
  • DOI: 10.1093/jrr/rrw097
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 放射線誘発ラット乳がんにおけるエピジェネティック異常 (2015)
  • Author(s): 臺野和広、高畠賢、西村まゆみ、森岡 孝満、西村由希子、今岡達彦、森山ひとみ、蒲地雄大、柿沼志津子、島田義也
  • Organizer: 第24回乳癌基礎研究会
  • Place of Presentation: 福島県いわき市
  • Year and Date: 2015-09-05
• [Presentation] 放射線による乳腺の発がん過程におけるDNAメチル化異常 (2014)
  • Author(s): 臺野和広、西村まゆみ、森岡孝満、ショウラー恵、今岡達彦、高畠賢、細木彩夏、島田義也
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-11-25 – 2014-11-27