2016 Fiscal Year Final Research Report
Epigenetic dysregulation of homeobox genes in radiation-induced rat mammary carcinogenesis
Project/Area Number |
26740022
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Risk sciences of radiation and chemicals
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Research Institution | National Institutes for Quantum and Radiological Science and Technology |
Principal Investigator |
Daino Kazuhiro 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 主任研究員(定常) (90543299)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | 放射線 / 乳がん / エピジェネティクス |
Outline of Final Research Achievements |
The mammary gland is one of the most sensitive organs to radiation carcinogenesis. However, epigenetic dysregulation in radiation-induced breast cancer have yet to be well characterized. In this study, we obtaiined results suggesting the involvement of epigenetic dysregulation of homeobox genes in radiation-induced rat mamamry carcinogenesis. In addition, we identified mutations in several epigenetic regulator genes in radiation-induced rat mammary carcinomas.
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Free Research Field |
放射線生物学
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