Epigenetic dysregulation of homeobox genes in radiation-induced rat mammary carcinogenesis
Project/Area Number |
26740022
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Risk sciences of radiation and chemicals
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Research Institution | National Institutes for Quantum and Radiological Science and Technology |
Principal Investigator |
Daino Kazuhiro 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 主任研究員(定常) (90543299)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 放射線 / 乳がん / エピジェネティクス / 発がん / 発生 |
Outline of Final Research Achievements |
The mammary gland is one of the most sensitive organs to radiation carcinogenesis. However, epigenetic dysregulation in radiation-induced breast cancer have yet to be well characterized. In this study, we obtaiined results suggesting the involvement of epigenetic dysregulation of homeobox genes in radiation-induced rat mamamry carcinogenesis. In addition, we identified mutations in several epigenetic regulator genes in radiation-induced rat mammary carcinomas.
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Report
(5 results)
Research Products
(4 results)
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[Journal Article] Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas2016
Author(s)
Kaye Showler , Mayumi Nishimura , Kazuhiro Daino , Tatsuhiko Imaoka , Yukiko Nishimura , Takamitsu Morioka , Benjamin J. Blyth , Toshiaki Kokubo , Masaru Takabatake , Maki Fukuda , Hitomi Moriyama , Shizuko Kakinuma , Masahiro Fukushi , Yoshiya Shimada
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Journal Title
Journal of radiation research
Volume: 58
Issue: 2
Pages: 183-194
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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