Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Outline of Final Research Achievements |
We have found that cyclic phosphatidic acid (cPA) has the function of promoting hyaluronic acid production on skin fibroblasts and synoviocyte. In this research project, we revealed that the expression of hyaluronan synthase 2 messenger RNA and protein is up-regulated by cPA treatment. In addition, we clarified the mRNA expression of hyaluronic acid-related proteins in human skin fibroblasts from donors of various ages (range, 0.7-69 years). As a result, it was revealed that the exertion of hyaluronan synthase did not decrease also in aged cells.
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