Parkinson's disease pathogenesis mediated by glycosylation of cholesterol
Project/Area Number |
26860199
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General medical chemistry
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Akiyama Hisako 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (80623462)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | パーキンソン病 / GBA / コレステリルグルコシド / コレステロール / グルコシルセラミド / 糖化コレステロール / 糖化ステロール / GBA1 |
Outline of Final Research Achievements |
β-Cholesterylglucoside (β-CG), a member of glycolipid, was successfully purified from embryonic chicken brains, and the presence of β-CG in vertebrate brain was demonstrated for the first time. An analytical system for β-CG was developed using liquid chromatography/mass spectrometry (LC/MS), and the expression levels of β-CG in the brains of Parkinson's disease (PD) model animals and postmortem PD patients were analyzed. β-CG increased in the brains of PD model animals compared to those of controls, and there was no significant difference in β-CG expression levels between the brains of postmortem PD patients and those of controls.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular beta-glucosidases2016
Author(s)
Marques, A. R. Mirzaian, M. Akiyama, H. Wisse, P. Ferraz, M. J. Gaspar, P. Ghauharali-van der Vlugt, K. Meijer, R. Giraldo, P. Alfonso, P. Irun, P. Dahl, M. Karlsson, S. Pavlova, E. V. Cox, T. M. Scheij, S. Verhoek, M. Ottenhoff, R. van Roomen, C. P. Pannu, N. S. van Eijk, M. Dekker, N. Boot, R. G., et al.
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Journal Title
Journal of Lipid Research
Volume: 57
Issue: 3
Pages: 451-463
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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