2016 Fiscal Year Final Research Report
Parkinson's disease pathogenesis mediated by glycosylation of cholesterol
Project/Area Number |
26860199
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General medical chemistry
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Akiyama Hisako 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (80623462)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | パーキンソン病 / GBA / コレステリルグルコシド / コレステロール / グルコシルセラミド |
Outline of Final Research Achievements |
β-Cholesterylglucoside (β-CG), a member of glycolipid, was successfully purified from embryonic chicken brains, and the presence of β-CG in vertebrate brain was demonstrated for the first time. An analytical system for β-CG was developed using liquid chromatography/mass spectrometry (LC/MS), and the expression levels of β-CG in the brains of Parkinson's disease (PD) model animals and postmortem PD patients were analyzed. β-CG increased in the brains of PD model animals compared to those of controls, and there was no significant difference in β-CG expression levels between the brains of postmortem PD patients and those of controls.
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Free Research Field |
脂質生化学
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