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Conformational change in transfer RNA is an early indicator of acute cellular damage

Research Project

Project/Area Number 26860624
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Kidney internal medicine
Research InstitutionTohoku University

Principal Investigator

Mishima Eikan  東北大学, 大学病院, 助教 (00706939)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordstRNA / 転移RNA / 急性腎障害 / 修飾核酸 / 1-メチルアデノシン / シュードウリジン / 酸化ストレス / バイオマーカー / rRNA / 修飾塩基 / tRNA / 慢性腎臓病 / 急性腎傷害 / 核酸
Outline of Final Research Achievements

We revealed that the detection of 1-methyladenosine, which is a modified nucleoside containing in transfer RNA, is a useful new biomarker for diagnosis of acute kidney injury (Mishima et al. JASN, 2014). In addition, we showed that circulating 1-methyladenosine levels are significantly associated with the mortality in the general population using the sample of Ohasama cohort study. Therefore, tRNA damage reflects early oxidative stress damage, and detection of tRNA damage may be a useful tool for identifying organ damage and forming a clinical prognosis. Furthermore, we developed a method for detecting RNA modifications called immuno-northern blotting analysis and confirmed its various capabilities (Mishima et al. PLoS ONE, 2015).

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (34 results)

All 2016 2015 2014 Other

All Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (15 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Detection of segmental renal ischemia by diffusion-weighted magnetic resonance imaging: Clinical utility for diagnosis of renovascular hypertension2016

    • Author(s)
      Eikan Mishima, Koichi Kikuchi, Hideki Ota, Yasutoshi Akiyama, Takehiro Suzuki, Kazumasa Seiji, Junichiro Hashimoto, Kei Takase, Takaaki Abe, Sadayoshi Ito.
    • Journal Title

      J Clin Hypertens

      Volume: - Issue: 4 Pages: 364-365

    • DOI

      10.1111/jch.12675

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detection of Segmental Renal Ischemia by Diffusion-Weighted Magnetic Resonance Imaging: Clinical Utility for Diagnosis of Renovascular Hypertension2016

    • Author(s)
      Mishima E, Kikuchi K, Ota H, Akiyama Y, Suzuki T, Seiji K, Hashimoto J, Takase K, Abe T, Ito S
    • Journal Title

      Journal of Clinical Hypertension

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腸内細菌と慢性腎臓病2016

    • Author(s)
      三島英換 福田真嗣 阿部高明
    • Journal Title

      アンチ・エイジング医学

      Volume: 12 Pages: 18-23

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides2015

    • Author(s)
      Mishima E, Jinno D, Akiyama Y, Itoh K, Nankumo S, Shima H, Kikuchi K, Takeuchi Y, Elkordy A, Suzuki T, Niizuma K, Ito S, Tomioka Y, Abe T
    • Journal Title

      PLos One

      Volume: 10 Issue: 11 Pages: e0143756-e0143756

    • DOI

      10.1371/journal.pone.0143756

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Periodontitis-associated septic pulmonary embolism caused by Actinomyces species identified by anaerobic culture of bronchoalveolar lavage fluid: a case report2015

    • Author(s)
      Endo S, Mishima E, Takeuchi Y, Ohi T, Ishida M, Yanai M, Kiyomoto H, Nagasawa T, Ito S
    • Journal Title

      BMC Infectious Diseases

      Volume: 15 Issue: 1 Pages: 552-556

    • DOI

      10.1186/s12879-015-1286-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of small renal ischemia in hypertension development: Renovascular hypertension caused by small branch artery stenosis2015

    • Author(s)
      Eikan Mishima, Junichiro Hashimoto, Yasutoshi Akiyama, Hisato Shima, Kazumasa Seiji, Kei Takase, Takaaki Abe, Sadayoshi Ito
    • Journal Title

      J Clin Hypertens

      Volume: 18 Issue: 3 Pages: 248-249

    • DOI

      10.1111/jch.12661

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases2015

    • Author(s)
      Suzuki T, Yamaguchi H, Kikusato M, Matsuhashi T, Matsuo A, Sato T, Oba Y, Watanabe S, Minaki D, Saigusa D, Shimbo H, Mori N, Mishima E, Shima H, Akiyama Y, Takeuchi Y, Yuri A, Kikuchi K, Toyohara T, Suzuki C, Kohzuki M, Anzai J, Mano N, Kure S, Yanagisawa T, Tomioka Y, Toyomizu M, Ito S, Osaka H, Hayashi K, Abe T
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 236 Issue: 3 Pages: 225-232

    • DOI

      10.1620/tjem.236.225

    • NAID

      130005083526

    • ISSN
      0040-8727, 1349-3329
    • URL

      https://pure.teikyo.jp/en/publications/f34848a7-3f52-481e-850d-fae28c8f317e

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Posterior reversible encephalopathy syndrome treated with renin-angiotensin system blockade2015

    • Author(s)
      Eikan Mishima, Junichiro Hashimoto, Yasutoshi Akiyama, Kazumasa Seiji, Kei Takase, Takaaki Abe, Sadayoshi Ito
    • Journal Title

      J Neurol Sci

      Volume: 355 Issue: 1-2 Pages: 219-221

    • DOI

      10.1016/j.jns.2015.06.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生活習慣病と酸塩基平衡:CKDと酸塩基平衡2015

    • Author(s)
      三島英換 阿部高明
    • Journal Title

      Medicament News

      Volume: 2206 Pages: 10-11

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Exonic Mutations in the SLC12A3 Gene Cause Exon Skipping and Premature Termination in Gitelman Syndrome2015

    • Author(s)
      竹内陽一、三島英換、他12名
    • Journal Title

      J Am Soc Nephrol

      Volume: 26 Issue: 2 Pages: 271-279

    • DOI

      10.1681/asn.2013091013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Conformational change in transfer RNA is an early indicator of acute cellular damage2014

    • Author(s)
      Mishima E, Inoue C, Saigusa D 他33名中13番目
    • Journal Title

      J Am Soc Nephrol.

      Volume: 25 Issue: 10 Pages: 2316

    • DOI

      10.1681/asn.2013091001

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD2014

    • Author(s)
      Eikan Mishima, Shinji Fukuda, Hisato Shima, Akiyoshi Hirayama, Yasutoshi Akiyama, Yoichi Takeuchi, Noriko N Fukuda, Takehiro Suzuki, Chitose Suzuki, Akinori Yuri, Koichi Kikuchi, Yoshihisa Tomioka, Sadayoshi Ito, Tomoyoshi Soga, and Takaaki Abe
    • Journal Title

      J Am Soc Nephrol

      Volume: 26 Issue: 8 Pages: 1-8

    • DOI

      10.1681/asn.2014060530

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 最新臨床高血圧学―高血圧治療の最前線― VII ライフステージ・タイプ別の高血圧の治療・管理 合併症を有する高血圧 CKD2014

    • Author(s)
      三島英換 伊藤貞嘉
    • Journal Title

      日本臨床

      Volume: 72 Pages: 454-458

    • Related Report
      2014 Research-status Report
  • [Journal Article] 各種臓器の血管病変と治療の展望 5)慢性腎臓病の病態と新規治療2014

    • Author(s)
      阿部高明 三島英換 伊藤邦彦 林謙一郎
    • Journal Title

      日本内科学会雑誌

      Volume: 103 Pages: 2158-2162

    • Related Report
      2014 Research-status Report
  • [Presentation] トランスポーターに関する最近の話題―特にSGLT1に関して―2016

    • Author(s)
      三島英換
    • Organizer
      Diabetes Seminar
    • Place of Presentation
      江陽グランドホテル(宮城県仙台市)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 遠隔テレビ会議システムを用いた津波被災地病院の外来・病棟の連携2015

    • Author(s)
      三島英換 清元秀泰
    • Organizer
      第19回遠隔医療学会学術集会
    • Place of Presentation
      仙台市戦災復興記念館(宮城県仙台市)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高血圧緊急症の診かた考え方2015

    • Author(s)
      清元秀泰 三島英換 伊藤貞嘉
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 粥状硬化性腎動脈狭窄症に対するステント治療の有効性と予後因子2015

    • Author(s)
      鈴木健弘、藤原昌彦、秋山泰利、三島英換、竹内陽一、鈴木千登世、横井良明、阿部高明、伊藤貞嘉
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] PTRA時の末梢塞栓により治療後に高血圧が残存した線維筋性異形成による腎血管性高血圧の一例2015

    • Author(s)
      向山靖乃 三島英換 秋山泰利 菊地晃一 鈴木健弘 橋本潤一郎 阿部高明 伊藤貞嘉
    • Organizer
      第45回日本腎臓学会東部学術集会
    • Place of Presentation
      東京ミッドタウン(東京都)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Evaluation of the impact of gut microbiota and intestinal environment on uremic toxins accumulation and pathophysiology of kidney disease2015

    • Author(s)
      Eikan Mishima
    • Organizer
      次世代腎研究アカデミー第2回学術集会
    • Place of Presentation
      経団連会館(東京都)
    • Year and Date
      2015-08-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腸内環境をターゲットにした慢性腎臓病の病態解明と新規治療法の開発2015

    • Author(s)
      三島 英換
    • Organizer
      成人病の病因・病態の解明に関する研究助成 第21 回研究発表会
    • Place of Presentation
      セントレジスホテル大阪(大阪府大阪市)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] CE-MSによる透析患者に特異的な尿毒素の網羅的探索2015

    • Author(s)
      秋山泰利,菊地晃一,島 久登,三島英換,伊藤貞嘉,阿部高明 中山昌明 曽我朋義
    • Organizer
      第60回透析医学会総会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 「腸腎連関―CKD進行における腸管および腸内細菌の関与―」2015

    • Author(s)
      三島英換
    • Organizer
      第9回宮城心・腎フォーラム
    • Place of Presentation
      ホテルメトロポリタン仙台(宮城県仙台市)
    • Year and Date
      2015-06-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 尿毒素蓄積における腸内細菌叢の関与 -無菌腎不全マウスとCE-TOFMSを用いた解析-2015

    • Author(s)
      三島英換、福田真嗣、秋山泰利、島久登、菊地晃一、鈴木健弘、伊藤貞嘉、阿部高明
    • Organizer
      第58回日本腎臓学会学術総会
    • Place of Presentation
      国際会議場(愛知県名古屋市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] ルビプロストンの腸内環境改善を介したアデニンCKDモデルにおける腎障害抑制効果2015

    • Author(s)
      三島英換、福田真嗣、秋山泰利、島久登、菊地晃一、鈴木健弘、伊藤貞嘉、阿部高明
    • Organizer
      第58回日本腎臓学会学術総会
    • Place of Presentation
      国際会議場(愛知県名古屋市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腸腎連関および虚血と腎2015

    • Author(s)
      三島英換
    • Organizer
      Kidney, Hypertension and Endocrinology Seminar
    • Place of Presentation
      艮陵会館(宮城県仙台市)
    • Year and Date
      2015-04-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Alteration of the intestinal environment by Lubiprostone is associated with amelioration of adenine induced CKD2015

    • Author(s)
      三島英換
    • Organizer
      The 4th Chronic kidney disease frontier meeting
    • Place of Presentation
      キャッスルプラザホテル(愛知県名古屋市)
    • Year and Date
      2015-02-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Lubiprostone Ameliorates the Progression of Chronic Kidney Disease By Altering the Intestinal Environment2014

    • Author(s)
      三島英換
    • Organizer
      Kidney Week 2014
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-13 – 2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] メタゲノムとメタボローム解析による腎不全時の腸内環境変化の検討2014

    • Author(s)
      三島英換
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Research-status Report
  • [Book] ヒトマイクロバイオーム研究最前線(第4編 治療法/治療薬開発 第1章 腸内環境改善による腎臓病の治療開発)2016

    • Author(s)
      三島英換 阿部高明
    • Total Pages
      429
    • Publisher
      NTS社
    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学病院腎高血圧内分泌科

    • URL

      http://www.int2.med.tohoku.ac.jp/goaisatsu.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学大学院医工学研究科 生体再生医工学講座 分子病態医工学分野

    • URL

      http://plaza.umin.ac.jp/~takaabe/

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Remarks] 東北大学 東北メディカル・メガバンク機構

    • URL

      http://www.megabank.tohoku.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学 医学系研究科 医学部 腎高血圧内分泌学分野

    • URL

      http://www.int2.med.tohoku.ac.jp/index.html

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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