Investigations for MUC5AC ecpresion in exramammary Paget disease

• Project/Area Number: 26860862
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Hokkaido University
• Principal Investigator: Hata Hiroo 北海道大学, 医学研究科, 助教 (90399915)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 皮膚腫瘍 / 乳房外パジェット病 / 皮膚悪性腫瘍

Outline of Final Research Achievements

Patients with in situ extramammary Paget's disease (EMPD) tend to have a good prognosis, although dermal invasion and metastasis are associated with significantly increased morbidity and mortality. No molecular markers that reflect invasiveness or progression have been established. We performed an initial microarray screening for in situ, invasive or metastatic lymph node lesions of EMPD, showing MUC-family overexpression. We analysed 44 specimens from 38 primary EMPD cases by immunohistochemical staining. We found that expressions of MUC5AC directly correlate with invasion and prognosis. MUC5AC expression was detected in 19 of 44 (43.2%) specimens. Invasive lesions and metastatic lymph nodes tended to express MUC5AC significantly higher than in situ lesions. Together, the degree of MUC5AC expression may correlate with the invasiveness and progression of EMPD, and may be a useful marker for identifying high-risk EMPD cases.

Research Products

• [Journal Article] Usefulness of dermoscopy in distinguishing benign lesion from angiosarcoma (2017)
  • Author(s): Sanada T, Hata H, Sato K, Imafuku K, Kitamura S, Yanagi T, Nomura T, Shimizu H.
  • Journal Title: Clin Exp Dermatol Volume: 印刷中
• [Journal Article] Modified Dufourmentel flap, easy to design and tailor to the defect. (2017)
  • Author(s): Imafuku K, Hata H, Yamaguchi Y, Inamura Y, Kitamura S, Yanagi T, Shimizu H.
  • Journal Title: J Dermatol. Volume: 44 Pages: 68-70
• [Journal Article] Ultrasonographic findings can identify ‘pseudoprogression’ under nivolumab therapy (2017)
  • Author(s): Imafuku K, Hata H, Kitamura S, Yanagi T, Shimizu H.
  • Journal Title: Br J Dermatol Volume: 印刷中
• [Journal Article] High infiltration of PD-1-positive cells with PD-L1 expression via IFN-γ is a favorable prognostic actor in cutaneous angiosarcoma. (2017)
  • Author(s): 72.Honda Y, Otsuka A*, Ono S, Yamamoto Y, Seidel JA, Morita S, Hirata M, Tatsuki R. Takenouchi T, Fujii K, Kanekura T, Okubo Y, Takahashi K, Yanagi T, Hoshina D, Hata H, Abe R, Fujimura T, Funakoshi T, Yoshino K, Masuzawa M, Amoh Y, Tanaka R, Fujisawa Y, Honda T, and Kabashima K.
  • Journal Title: Oncoimmunology Volume: 印刷中
• [Remarks] 北海道大学皮膚科 ホームページ
  • URL: http://www.derm-hokudai.jp/jp/