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Analysis of CD271-positive Lung Cancer Stem Cells

Research Project

Project/Area Number 26861132
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory surgery
Research InstitutionMiyagi Prefectural Hospital Organization Miyagi Cancer Center

Principal Investigator

SUGAWARA SAYURI  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 共同研究員 (10728190)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsがん幹細胞 / 頭頸部癌 / レトロマー / 癌 / 扁平上皮癌
Outline of Final Research Achievements

Cancer stem cell theory applies to a number of malignant cancers including lung cancer, and specific markers to identify such stem cells remain to be elucidated. To investigate a potential contribution of CD271 in Squamous cell cancer, CD271-positive cell population was analyzed. Patient-derived xenograft (PDX) lines were successfully established. CD271+ population sorted from PDX-derived SCC showed an enhanced tumor-formation capability in highly immunodeficient NOG mice. Both of the CD271-positive and -negative cells are included in tumors generated from CD271-cell derived tumors, which suggested that the CD271+ population could undergo differentiation into CD271- one. Tumor-spheres contained more CD271+ cells than those from the normal in vitro culture condition. In in vivo tumors treated by the CDDP treatment, contained significantly more CD271+ cells, suggesting that CD271+ cells are chemo-resistant. The current findings suggested that CD271 is a novel marker for SCC stem cells.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2014

All Presentation (1 results)

  • [Presentation] CD271 plays critical roles in invading cancer cells in hypopharyngeal carcinoma.2014

    • Author(s)
      Mochizuki, M. Sugawara, S., Tamai, K, Tanaka, N.
    • Organizer
      第73回日本癌学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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