2023 Fiscal Year Final Research Report

Grant-in-Aid for Scientific Research on Innovative Areas "Totipotency" steering group

Administrative Group

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Project Area	Program of totipotency: From decoding to designing
Project/Area Number	19H05749
Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Allocation Type	Single-year Grants
Review Section	Biological Sciences
Research Institution	Institute of Physical and Chemical Research
Principal Investigator	Ogura Atsuo 国立研究開発法人理化学研究所, バイオリソース研究センター, 室長 (20194524)
Co-Investigator(Kenkyū-buntansha)	伊川正人大阪大学, 微生物病研究所, 教授 (20304066) 篠原隆司京都大学, 医学研究科, 教授 (30322770)
Project Period (FY)	2019-06-28 – 2024-03-31
Keywords	全能性 / ゲノム再プログラム化 / 核移植クローン / 受精 / 胎盤
Outline of Final Research Achievements	In the "Totipotency Program", experts in related fields worked together to challenge the molecular basis of the mechanism of totipotency. The objectives of the Administrative Group are to maximize research results, to disseminate the achievements to society, and to foster young researchers who will lead the next generation of this area. By the end of the research term (5 years), 393 original papers and 63 review articles were published and invited lectures (163 domestic and 83 international) were given. In addition, 29 joint research papers were published as a result of active collaboration within the grant group. Three domestic and one international open symposia and three workshop meetings for young researchers were held. Thirty in-depth introductory review series for outstanding publications were held by the first authors. Technical support was provided; genetically engineered animal production, ICSI/cloning, sequencing analysis, stem cell establishment, and chromosome analysis.
Free Research Field	発生工学
Academic Significance and Societal Importance of the Research Achievements	全能性は、1個の細胞が、発生付属器（胎盤など）を含めた完全な個体発生を支える能力と定義されるが、その分子メカニズムは不明である。本領域により、多分野の最新の知見と解析技術が有機的に結合し、全能性の確立から消去までにおける多くの分子メカニズムが明らかになった。その成果は、基礎生物学の新たな知見（全能性状態のナイーブなエピゲノム、胚性遺伝子発現メカニズムなど）から産業・医学領域応用（畜産、生殖医療、移植医療）まで多岐に渡る波及効果が期待できる。また、計画および公募研究では、多くの若手研究者が活躍し、PIへと成長した。将来的に全能性のサイエンスおよびその周辺領域の発展に貢献すると期待される。