The effect of osteoporotic fractures for progress of arteriosclerosis based on bone vascular correlation: 20-years follow-up of a large cohort study with randomized sampled women

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04789
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Osaka Medical College
• Principal Investigator: TAMAKI Junko 大阪医科大学, 医学部, 教授 (90326356)
• Co-Investigator(Kenkyū-buntansha): 佐藤 裕保 仁愛大学, 人間生活学部, 教授 (10337115) ; 臼田 寛 大阪医科大学, 医学部, 准教授 (80298752) ; 千葉 康敬 近畿大学, 医学部附属病院, 准教授 (80362474) ; 伊木 雅之 近畿大学, 医学部, 教授 (50184388) ; 梶田 悦子 名古屋大学, 医学系研究科(保健), 教授 (50135373) ; 由良 晶子 近畿大学, 医学部, 講師 (80142595)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 骨粗鬆症 / 骨粗鬆症性骨折 / 動脈硬化 / コホート研究 / 地域在住女性

Outline of Final Research Achievements

We investigated the relationship of osteoporosis and osteoporotic fracture to progress of arteriosclerosis. Osteoporotic vertebral fracture events were associated with increased risks of vascular calcification at carotid artery. We also observed increased risks of arterial stiffness, which was defined as brachial-ankle pulse wave velocity ≧1800cm/sec, by 30% per 1SD decrease in T-score of BMD. The present findings showed that low bone mass and osteoporotic vertebral fracture events were associated with the increased rinks of progress of arteriosclerosis in community-dwelling Japanese women.

Free Research Field

疫学、公衆衛生学