Elucidation of molecular mechanism of lipid mediator involved in metastatic ability of biliary tract cancer / pancreatic cancer and clinical application

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04927
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Niigata University
• Principal Investigator: WAKAI TOSHIFUMI 新潟大学, 医歯学系, 教授 (50372470)
• Co-Investigator(Kenkyū-buntansha): 永橋 昌幸 新潟大学, 医歯学総合病院, 講師 (30743918) ; 松田 康伸 新潟大学, 医歯学系, 准教授 (40334669) ; 小林 隆 新潟大学, 医歯学総合病院, 講師 (40464010) ; 五十嵐 道弘 新潟大学, 医歯学系, 教授 (50193173) ; 坂田 純 新潟大学, 医歯学系, 講師 (70447605) ; 味岡 洋一 新潟大学, 医歯学系, 教授 (80222610) ; 小杉 伸一 新潟大学, 医歯学総合病院, 特任教授 (90401736)
• Co-Investigator(Renkei-kenkyūsha): Komatsu Masaaki 新潟大学, 医歯学系, 教授 (90356254)
• Research Collaborator: Sarah Spiegel バージニア州立大学, 教授 ; Hylemon Phillip B. バージニア州立大学, 教授 ; Takabe Kazuaki Roswell Park Cancer Institution, 教授
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脂質メディエーター / 胆道外科学 / 膵臓外科学

Outline of Final Research Achievements

We have developed a method to measure sphingosine-1-phosphate levels in the interstitial fluid that bathes cancer cells in the tumor microenvironment, and reported that high levels of sphingosine-1-phosphate exist in the tumor interstitial fluid. Importantly, sphingosine-1-phosphate can be secreted from cancer cells and non-cancer components such as immune cells and vascular/lymphatic endothelial cells in the tumor microenvironment. We elucidate the roles of sphingosine-1-phosphate in the interaction between cancer and non-cancer cells in tumor microenvironment, and discuss future possibilities for targeted therapies against sphingosine-1-phosphate signaling for cancer patients.

Free Research Field

消化器外科学