Development of dentin remineralization/regeneration thchnology toward creation of new caries treatment

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H05024
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: SAITO TAKASHI 北海道医療大学, 歯学部, 教授 (40265070)
• Co-Investigator(Kenkyū-buntansha): 村田 勝 北海道医療大学, 歯学部, 教授 (00260662) ; 伊藤 修一 北海道医療大学, 歯学部, 准教授 (50382495) ; 松田 康裕 北海道医療大学, 歯学部, 講師 (50431317) ; 別所 和久 京都大学, 医学研究科, 教授 (90229138)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 象牙質再石灰化

Outline of Final Research Achievements

In this research, we aimed to obtain knowledge that aids in the development of new caries therapy by developing and disseminating multifunctional adhesive restoration materials/technology based on hybrid technology of dentin remineralization/regeneration technology. Dentin phosphoprotein derived peptide induced proliferation, differentiation and mineralization of odontoblasts. Moreover, it was suggested that by adding fish derived collagen as a safe carrier and/or nephronectin, laminin as co-factors enhancing the action of the peptide, it becomes possible to develop multifunctional adhesive restoration material.

Free Research Field

歯科保存学