Development of novel treatment strategies targeting the R-spondin-LGR-APC axis in glioblastoma stem cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06838
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Chiba University (2016-2017); Tokai University (2015)
• Principal Investigator: NASU Ryo 千葉大学, 大学院医学研究院, 特任助教 (30466859)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: がん / がん幹細胞 / 膠芽腫 / Wntシグナル / がん免疫

Outline of Final Research Achievements

Glioblastoma is the most common and aggressive malignant brain tumor in adults. In this study, we tried to develop a new therapy that targets the interaction of glioblastoma stem cells with their specific microenvironments. We found a crucial role of the R-spondin-LGR5-APC axis in the control of Wnt signaling in glioblastoma stem cells. Moreover, R-spondin/Wnt stimuli activate Wnt signaling via promoting the phosphorylation of Axin1 at T160. Thus, small molecules that inhibit Axin1 T160 phosphorylation hold promise as novel anti-tumor reagents.

Free Research Field

腫瘍生物学