2017 Fiscal Year Final Research Report
The evolutionary origin of the vertebrate neural crest cells
Project/Area Number |
15K07091
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Developmental biology
|
Research Institution | National Institute of Advanced Industrial Science and Technology |
Principal Investigator |
OHTSUKA YUKIO 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (90344192)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | 神経堤 / 細胞移動 / 末梢神経 / ホヤ |
Outline of Final Research Achievements |
In ascidians, invertebrate chordates, the neural plate border gives rise to peripheral neurons and pigment cells, as in vertebrates. Here I identified migratory neural progenitors derived from the neural plate border in Halocynthia roretzi. Fluorescence live cell imaging showed that these progenitors migrate anteriorly along the tail dorsal midline from tail tip during the tailbud stage. Furthermore, I found that migratory neural progenitors express neurogenin and that neurogenin expression in migratory neural progenitors requires MEK and retinoic acid signaling.
|
Free Research Field |
発生生物学
|