2017 Fiscal Year Final Research Report
Analysis of interrelationships of stress, biological clock, and health conditions focusing on salivary biomarkers as indicator
| Project/Area Number |
15K07740
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBATA Shigenobu 早稲田大学, 理工学術院, 教授 (10162629)
MATSUDA Hiroshi 東京農工大学, 農学研究科, 教授 (80145820)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | バイオマーカー / ストレス / サーカディアンリズム / 霊長類 |
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| Outline of Final Research Achievements |
Stress disrupts biological rhythm, and causes various diseases. The aim of this study was to analyze the effect of stress on biological rhythm from the viewpoint of biomarkers in saliva and to find stress markers that can be used in various animal species. Studies using mouse and monkey revealed that the stress decreases immunoglobulin A (IgA) in saliva, and eliminates the circadian rhythm of salivary IgA. Salivary IgA may be a biomarker that can simultaneously monitor biological rhythm and stress response.
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| Free Research Field |
動物生命科学
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