2017 Fiscal Year Final Research Report
Identification of innate immune ligands to induce the protection from MRSA infection
| Project/Area Number |
15K08056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Research Collaborator |
LEE Bok-Leul 釜山大学校, 薬学部, 教授
TAKAHASHI Kazue Massachusetts General Hospital, Assistant Professor
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 細菌宿主相互作用 / 樹状細胞 / 黄色ブドウ球菌 / 免疫賦活化 / 細胞壁タイコ酸 |
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| Outline of Final Research Achievements |
Staphylococcus aureus infection induces IL-23 that is critical for its biological defense, however the bacterial ligand molecules for the IL-23-induction have been unknown. We established a bioassay system to evaluate the IL-23 inducing activity by using a cultured human dendritic cell line and found that there were at least two molecules for the induction; one was wall teichoic acids (WTA) and the other was unidentified. Biochemical analyses using cell wall fractions derived from WTA modification enzymes revealed that a complete modified structure of WTA was not necessary for the IL-23 secretion.
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| Free Research Field |
微生物薬品化学
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