Development of anti-hepatitis virus strategy based on proteomics

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08493
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: University of Yamanashi
• Principal Investigator: MORIISHI Kohji 山梨大学, 大学院総合研究部, 教授 (90260273)
• Co-Investigator(Renkei-kenkyūsha): YAMASHITA Atsuya 山梨大学, 大学院総合研究部, 助教 (00334871) ; KASAI Hirotake 山梨大学, 大学院総合研究部, 助教 (20324189) ; TANAKA Tomohisa 山梨大学, 大学院総合研究部, 助教 (30585310)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: HCV / C型肝炎 / HBV / B型肝炎 / 抗ウイルス剤 / 宿主蛋白質

Outline of Final Research Achievements

The aim of this study was identification of antiviral compounds that targeted host agents interacting proteins of hepatitis B and C viruses (HBV and HCV) based on proteomics information. FKBP6 and HM13 were identified as essential host proteins for HCV replication and the viral particle production and its pathogenicity. DM-CHX and cinnamic acid derivatives, which target them, prevented HCV replication and production. Furthermore, pTEFb inhibitor could suppress HBV replication and production. These results will contribute to development of novel antiviral agents targeting production and pathogenicity of HBV and HCV

Free Research Field

ウイルス学