2017 Fiscal Year Final Research Report
Analysis of factors involved in the establishment of asymptomatic carrier state in HTLV-1 infected humanized mice
| Project/Area Number |
15K08506
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | HTLV-1 / ATL / ヒト化マウス / Tax / HBZ |
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| Outline of Final Research Achievements |
In the course of HTLV-1 infection in humanized mouse, highly-Tax-expressing infected-T-cell clones expanded preferentially in the first four weeks of infection but subsequently were reduced provably due to the induction of cytotoxic T-lymphocytes against Tax in the later period. Instead, after eight weeks post infection, infected clones were composed of T-cells expressing larger amount of HBZ most likely because of reverse orientation of the provirus integration to the direction of host gene transcription in the introns. Thus, the elimination of Tax-expressing clones and the selective growth of HBZ expressing clones are suggested to be a major factor to sustain the slow growth of infected cells to establish the asymptomatic carrier state of infection.
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| Free Research Field |
ウイルス学
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