Search for new potential drug targets for Hepatitis B virus genome replication based on chemical biology

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08507
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: Microbial Chemistry Research Foundation
• Principal Investigator: YAMASAKI Manabu 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 (50442570)
• Co-Investigator(Renkei-kenkyūsha): SAITO Izumu 公益財団法人微生物化学研究会, 微生物化学研究所, チームリーダー (70158913) ; KANEGAE Yumi 東京慈恵会医科大学, 医学部, 准教授 (80251453) ; KONDO Saki 東京大学, 医科学研究所, 助教 (80451871) ; IGARASHI Masayuki 公益財団法人微生物化学研究会, 微生物化学研究所, 部長 (40260137) ; SAWA Ryuichi 公益財団法人微生物化学研究会, 微生物化学研究所, 上席室長 (50235454)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: B型肝炎ウイルス / 抗ウイルス薬 / ゲノム複製 / 創薬標的分子 / ケミカルバイオロジー

Outline of Final Research Achievements

There is a need for novel drug targets for treatment of chronic Hepatitis B virus (HBV) infection to expand our therapeutic repertoire. In this study, we screened in-house compound library and microbial fermentation broths using adenovirus-mediated efficient virus genome replication system, and performed mode-of-action studies using hit compounds for identification of new potential drug targets. In the course of our screening program, we identified three selective inhibitors, and found that the compound among them has a potential activity to exert host anti-HBV responses in addition to direct antiviral activity.

Free Research Field

医歯薬学