2017 Fiscal Year Final Research Report
Functional analysis of small RNAs involved in tumorigenesis of a new molecular subtype of colorectal cancer, and investigation of their new molecular targets
| Project/Area Number |
15K08962
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
TAKAHASHI Hidekazu 石巻赤十字病院, 腫瘍内科, 医師
KOBAYASHI Akihiro 東北大学, 加齢医学研究所, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | miRNA / BRAF / 抗EGFR抗体 |
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| Outline of Final Research Achievements |
This study was aimed to identify specific miRNAs, a class of small RNAs, that could be involved in oncogenesis of a molecular subgroup, BRAF-mutated colorectal cancer, and clarify biological functions of the miRNAs. A genome-wide miRNA expression analysis and functional analysis using colorectal cancer cell lines revealed that a miRNA, significantly down-regulated in BRAF-mutated colorectal cancer, acts as a tumor suppressor and affects sensitivity to anti-EGFR therapy in colorectal cancer. We are now investigating the mechanism underlying the dysregulation of this miRNA and analyzing the miRNA-involving signaling pathways that may relate to the carcinogenesis and/or chemosensitivity. The results could lead to further developing novel targeted therapies of colorectal cancer.
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| Free Research Field |
臨床腫瘍学
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