2017 Fiscal Year Final Research Report
Mechanisms of maintenance of podocyte cytoskeletal structure against metabolic stress associated with diabetes and Development of novel therapeutic strategies
| Project/Area Number |
15K09247
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川上 貴久 東京大学, 医学部附属病院, 助教 (10722093)
稲城 玲子 東京大学, 医学部附属病院, 特任准教授 (50232509)
南学 正臣 東京大学, 医学部附属病院, 教授 (90311620)
田中 哲洋 東京大学, 医学部附属病院, 講師 (90508079)
加藤 秀樹 東京大学, 医学部附属病院, 講師 (90625237)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 糸球体足細胞 / 蛋白尿 / 細胞骨格 / 高グルコース / TGF-β1 |
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| Outline of Final Research Achievements |
We have carried out this project to determine the mechanisms of cytoskeletal derangement associated with metabolic stresses in podocytes leading to development and increase of proteinuria. In this project, we observed the changes in cytoskeletal architecture and migration of podocytes in response to several metabolic stress associated with diabetes. Interestingly, we found that altered expression of several cell cycle regulators were associated with those cellular changes. Moreover, our experimental data suggest that vitamin D might have a protective role against diabetic metabolic stresses through these pathways. We hope that novel therapeutic strategies against diabetic kidney disease will be developed by advance in this research project.
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| Free Research Field |
腎臓内科学
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