Differentiation of early Alzheimer's disease by the diffusion kurtosis imaging

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09357
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Iwate Medical University
• Principal Investigator: Takahashi Junko 岩手医科大学, 医学部, 助教 (00423989)
• Co-Investigator(Kenkyū-buntansha): 米澤 久司 岩手医科大学, 医学部, 准教授 (20240377) ; 寺山 靖夫 岩手医科大学, 医学部, 教授 (70146596) ; 佐々木 真理 岩手医科大学, 医学部, 教授 (80205864)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: アルツハイマー病 / 軽度認知障害 / MRI / 拡散尖度画像 / 拡散テンソル画像

Outline of Final Research Achievements

By identifying cases that progress to Alzheimer's disease (AD) more accurately at the mild cognitive impairment (MCI) stage it becomes possible to extract more appropriate cases when curative drugs are used. In this study, the parahippocampal cingulum bundles were three dimensionally extracted using MRI, and the mean parameter within the volume was automatically measured. When comparing between patients with MCI and healthy subjects, significant differences were observed in the mean kurtosis(MK), mean diffusivity(MD) in the parahippocampal cingulum bundle. In the ROC analysis of patients with MCI and the healthy subjects, the sensitivity and specificity were 65.0% and 85%, respectively, when the cut-off value was 0.69, whereas for the MD, the sensitivity and specificity were 84.6% and 75%, respectively, when the cut-off value was 0.87. When combining MD and MK measurements, the difference between patients with MCI and the healthy subjects could be more accurately distinguished.

Free Research Field

神経内科