Early diagnosis of dementia with Lewy bodies based on diagnostic imaging: pathologic-diagnostic imaging correlation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09957
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tottori University
• Principal Investigator: Ogawa Toshihide 鳥取大学, 医学部, 教授 (00125709)
• Co-Investigator(Kenkyū-buntansha): 藤井 進也 鳥取大学, 医学部附属病院, 講師 (10379638) ; 篠原 祐樹 鳥取大学, 医学部附属病院, 助教 (60462470)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: レビー小体型認知症 / パーキンソン病 / 神経メラニンMRイメージング / ドーパミントランスポータイメージング / MIBG心筋シンチグラム

Outline of Final Research Achievements

We propose a diagnostic approach for dementia with Lewy bodies (DLB) and its related neurodegenerative diseases using MR imaging and SPECT. First, conventional MR imaging and neuromelanin sensitive MR imaging should be applied to the patients with movement disorders and/or dementia. Second, MIBG myocardial scintigraphy should be selected according to these MR imaging findings. Moreover, a combination of these neuroimaging methods including SPECT with 123I-FP-CIT is a useful and practical approach for the differential diagnosis and confirmation of DLB and its related neurodegenerative diseases.

Free Research Field

神経放射線医学，脳神経核医学