2017 Fiscal Year Final Research Report
Development of a protection method to prevent spinal cord ischemia by promoting spinal collateral circulation with proangiogenic cytokine-inducer.
| Project/Area Number |
15K10243
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
倉谷 徹 大阪大学, 医学系研究科, 寄附講座教授 (90448035)
鳥飼 慶 大阪大学, 医学系研究科, 講師 (70364792)
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| Research Collaborator |
MIYAGAWA Shigeru
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 大動脈瘤 / 脊髄虚血 |
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| Outline of Final Research Achievements |
The objective of this study is to develop a protection method to prevent spinal cord ischemia by promoting spinal collateral circulation with proangiogenic cytokine-inducer (ONO-1301). We found that intravenously injected ONO-1301 incorporated liposome-based nanoparticle was selectively accumulated in ischemic area. Histologically, gene expression of proangiogenic cytokines of hepatocyte growth factor or angiopoietin-1 in the ischemic area were significantly higher and CD31-positive capillaries in the ischemic area were significantly greater in the ONO-1301 group.
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| Free Research Field |
大動脈疾患
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