Can inflammation worsen the prognosis of severe subarachnoid hemorrhage

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10284
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Hokkaido University
• Principal Investigator: HOKARI Masaaki 北海道大学, 医学研究院, 客員研究員 (30622807)
• Co-Investigator(Kenkyū-buntansha): 七戸 秀夫 北海道大学, 大学病院, 准教授 (80374479) ; 中山 若樹 北海道大学, 医学研究院, 講師 (40421961) ; 寳金 清博 北海道大学, 大学病院, 教授 (90229146)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ミノサイクリン / くも膜下出血 / 炎症 / 低体温

Outline of Final Research Achievements

Inflammation process following severe subarachnoid hemorrhage may exacerbate neuronal damage. Recent studies have revealed that microglia may play an important role in brain inflammation after cerebral damage, however the role of microglia after subarachnoid hemorrhage is not well understood. The authors have conducted a basic research to figure out whether hypothermia and minocycline which is the suppresive drug of microglia will work against inflammation after subarachnoid hemorrhage.

Free Research Field

脳卒中