2017 Fiscal Year Final Research Report
Investigation of MDSC-specific marker as prognostic factor and therapeutic target of patients with advanced renal cell carcinoma
| Project/Area Number |
15K10574
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
武田 裕司 山形大学, 医学部, 助教 (90302299)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 腎細胞癌 / MDSC / GPI-80 |
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| Outline of Final Research Achievements |
The patterns of myeloid-derived suppressor cells (MDSC) in peripheral blood of patients with metastatic renal cell carcinoma (mRCC) were studied and useful prognostic factors were examined. Myeloid cell antigens on peripheral blood neutrophilic cells and monocytic cells in mRCC patients were measured by flow cytometry. A comprehensive RNA expression in polymorphonuclear leukocytes (PMN) was also analyzed. As a result, the MFI (average fluorescence intensity) or CV (coefficient variation) of CD16, GPI-80, and LAP-1 on neutrophilic cells or monocytic cells were increased. It was indicate that the diversity of the myeloid cell population is increased. In addition, mRNA expression of PMNs was different between healthy volunteers and mRCC patients. MFI of GPI-80 on monocytic cells was associated with the clinical outcome and considered to be a useful prognostic marker of mRCC.
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| Free Research Field |
泌尿器科学
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