Elucidation of the role of inflammation and apoptosis and development of a new target in age-related macular degeneration

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10875
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Nagoya City University
• Principal Investigator: Hirano Yoshio 名古屋市立大学, 大学院医学研究科, 講師 (40405163)
• Co-Investigator(Kenkyū-buntansha): 野崎 実穂 名古屋市立大学, 大学院医学研究科, 講師 (00295601) ; 安川 力 名古屋市立大学, 大学院医学研究科, 准教授 (00324632) ; 小椋 祐一郎 名古屋市立大学, 大学院医学研究科, 教授 (70191963)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脈絡膜新生血管 / 炎症 / アポトーシス / 網膜色素上皮

Outline of Final Research Achievements

Age-related macular degeneration (AMD) is a vision-threatening disease and the number of patients continues to grow. Recently developed anti-vascular endothelial growth factor (VEGF) therapy for choroidal neovascularization (CNV) has revolutionized the treatment in visual improvement. However, there are still ineffective cases or most of the patients need multiple injections of anti-VEGF agents. We aimed to elucidate the pathophysiology of CNV using mouse laser CNV model to investigate a new target for CNV. Inflammation and apoptosis were associated with the CNV formation. Therefore, to control inflammation and apoptosis chould be an alternative therapy to suppress vision loss associated with CNV in AMD.

Free Research Field

網膜硝子体