2017 Fiscal Year Final Research Report
Clofibrate produce IL-1Ra and inhibit the experimental periodontitis
| Project/Area Number |
15K11402
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉成 伸夫 松本歯科大学, 歯学部, 教授 (20231699)
小出 雅則 松本歯科大学, 総合歯科医学研究所, 講師 (10367617)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | クロフィブラート / IL-1Ra / IL-1 / 実験的歯周炎 |
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| Outline of Final Research Achievements |
Inflammatory cytokines are deeply involved in the onset and progression of periodontal disease. It has been reported that hyperlipidemic drug of clofibrate produce high levels of IL-1Ra from brain macrophage, therefore we investigated the IL-1Ra production from mouse macrophage stimulated with lipopolysaccharide of periodontal pathogenic bacteria. Expression of IL-1β and TNF-α from mouse macrophage was significantly increased. Expression of IL-1Ra, IL-6, IL-1α and IL-1 receptor (IL-1R1) was same levels as that of the control, although the expression trend of SOCS3 was somewhat increased.
These findings suggested that clofibrate alone may act to increase a periodontal tissues inflammation.
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| Free Research Field |
歯学
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