The importance of polyamine activation in pulmonary hypertension

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15318
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: University of Tsukuba
• Principal Investigator: SAKAI Satoshi 筑波大学, 医学医療系, 講師 (30282362)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 肺高血圧症 / ポリアミン / メタボローム解析

Outline of Final Research Achievements

It occurs that marked increase of pulmonary arterial smooth muscle cells (PASMCs) in pulmonary arterial hypertension (PAH). By metabolomics analysis, the concentration of polyamine was significantly elevated in the lungs of hypoxia-induced PAH mice. By microarray analysis, the gene expression of S-adenosyl methionine decarboxylase in the lungs was markedly increased in PAH mice. Taken together, the augmentation of polyamine concentration would be due to the increased synthesis of decarboxylated S-adenosyl methionine, which was induced by the enhanced activity of S-adenosyl methionine decarboxylase. Because polyamine contributes to the proliferation of cancer cells, the increase of polyamine production in the lungs would also be involved in the enhanced proliferation of PASMCs in PAH, probably in a similar fashion.

Free Research Field

循環器内科学