Treatment of Lung Ischemia-reperfusion injury by Muse cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15514
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Tohoku University
• Principal Investigator: OKADA Yoshinori 東北大学, 加齢医学研究所, 教授 (90323104)
• Co-Investigator(Renkei-kenkyūsha): DEZAWA Mari 東北大学, 医学部, 教授 (50272323)
• Research Collaborator: YABUKI Hiroshi 東北大学, 医学系研究科, 大学院生
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 肺移植 / 虚血・再灌流傷害 / 間葉系幹細胞 / Muse細胞

Outline of Final Research Achievements

Lung ischemia-reperfusion injury is a signify complication after lung transplantation. We examined the effect of Multi-lineage differentiating Stress Enduring cell (Muse cells) on ameliorating lung ischemia-reperfusion injury in a rat model. Human Muse cells (Muse group), human mesenchymal stem cells (MSC group) or PBS (Vehicle group) were infused into the left pulmonary artery after 2-hour ischemia and subsequent reperfusion. On days 3 and 5 after reperfusion, the Muse group showed the most favorable arterial blood gas, left lung compliance and histological scores for IR injury among 3 groups. The present study indicated that administration of Muse cells ameliorate lung ischemia-reperfusion injury in a rat model.

Free Research Field

呼吸器外科学