2016 Fiscal Year Final Research Report
The effect of stealth-typed midazolam-encapsulating nano drug carrier on bioavailability of midazolam following oral administration
| Project/Area Number |
15K15739
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
Miyawaki Takuya 岡山大学, 医歯薬学総合研究科, 教授 (00219825)
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| Research Collaborator |
MORI Megumi
TANIMURA Hiroshi
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 歯学 / 薬理学 / 麻酔薬 / リポソーム |
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| Outline of Final Research Achievements |
The purpose of the present study was to find the appropriate condition to produce miniaturized midazolam-encapsulating liposome as a stealth-typed drug carrier and to evaluate the effect of the miniaturized liposome-encapsulated midazolam on the bioavailability of midazolam and investigate its mechanism. As a result we found the appropriate condition to produce miniaturized midazolam-encapsulating liposome. The miniaturized midazolam-encapsulating liposomes produced in that condition increased the bioavailability of midazolam on oral administration, and the mechanism was suggested to be due to the increase of absorption of miniaturized midazolam-encapsulating liposomes in the intestine.
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| Free Research Field |
歯科麻酔学
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