Investigation of schizophrenia-like behavioral phenotypes in mice with temporal regulation of calcineurin activity

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18379
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Fujita Health University
• Principal Investigator: Nakao Akito 藤田保健衛生大学, 総合医科学研究所, 助教 (30748926)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 精神疾患 / モデルマウス / 行動解析

Outline of Final Research Achievements

Forebrain-specific calcineurin knockout mice show schizophrenia-like behavioral phenotypes such as impaired working memory and increased locomotor activity. In the present study, we examined the effects of the change of calcineurin activity during the developmental stage using tetracycline-regulated gene expression system. Behavioral analyses suggest that calcineurin activity after the developmental stage may be involved in increased locomotor activity.

Free Research Field

神経科学