2016 Fiscal Year Final Research Report
Endothelial Stem Cell System in the Tumor Vasculature
| Project/Area Number |
15K18409
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
|
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 腫瘍血管 / 血管内皮幹細胞 / 薬剤耐性 / 血管新生 / SP細胞 |
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| Outline of Final Research Achievements |
We have been studying the endothelial stem cell system in the vasculature. Here we identified this endothelial stem cell system in the tumor vasculature. In the tumor vasculature, the percentage of endothelial stem cells was significantly increased compared to normal tissue. Moreover, we showed endothelial hierarchy by transplantation model. By gene expression analysis, we found that endothelial stem cell in the tumor highly express drug resistance genes. Addition of an inhibitor which blocks the function of drug resistance protein inhibited the colony formation of endothelial stem cells. Furthermore, administration of this inhibitor to the tumor bearing mice induced regression of tumor size of these mice. Our results suggest the existence of endothelial hierarchy system in the tumor vasculature. Targeting this system may be a promising therapeutic target in the future.
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| Free Research Field |
血管生物学
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