A research to reveal the cell-cell recognition mechanisms to maintain compartment boundaries

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18536
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cell biology
• Research Institution: Tohoku University (2016-2017); Institute of Physical and Chemical Research (2015)
• Principal Investigator: Umetsu Daiki 東北大学, 生命科学研究科, 助教 (60620474)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: コンパートメント境界 / 組織構築 / 自己組織化 / 細胞の選り分け / 細胞間認識 / ショウジョウバエ

Outline of Final Research Achievements

The formation of straight compartment boundaries separating groups of cells is an evolutionarily conserved strategy for tissue growth and patterning during multicellular organism development. In this project, I aimed to reveal the mechanisms that underlie this phenomenon by considering as a fundamental process important for tissue organization by cellular self-organization. By using a recently developed genome editing technology, I found that a molecule, whose vertebrate homologues function in immune cells to recognize non-self molecules, plays an important role in maintaining compartment boundaries in a Drosophila epithelial tissue.

Free Research Field

発生生物学、細胞生物学