2017 Fiscal Year Final Research Report
Evaluation of genetic factors for drug sensitivity in childhood leukemia by genome wide association analysis
| Project/Area Number |
15K18932
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ゲノムワイド関連解析 / 抗悪性腫瘍薬 / 小児急性リンパ性白血病 / 感受性 / 6-メルカプトプリン |
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| Outline of Final Research Achievements |
The treatment for childhood acute lymphoblastic leukemia treatment is used combined several anti-cancer drugs. We analyzed the association between genetic variants and the therapy related clinical information, which are drug-induced toxicities, allergy and drug concentration, by genome wide association study (GWAS). We found that 6-MP tolerability during maintenance therapy was significantly associated with the genetic variation of MED4 and NUDT15, and NEGR1 was possible association factor of tolerability. The MTHFR variant was possible association factor of delaying methotrexate level after high dose methotrexate treatment.
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| Free Research Field |
ファーマコジェネティクス
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