2016 Fiscal Year Final Research Report
Elucidation of regulation of osteogenesis and chondrogenesis by Hippo pathway
| Project/Area Number |
15K19026
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
Goto Hiroki 九州大学, 生体防御医学研究所, 助教 (20734495)
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| Research Collaborator |
NISHIO Miki
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | Hippo経路 / シグナル伝達 |
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| Outline of Final Research Achievements |
Osteoblast-specific Mob1a/1b double homozygous mutant mice showed osteosclerosis with the growth of osteoblasts. Chondrocyte-specific Mob1a/1b double homozygous mutant mice showed short-limb skeletal dysplasia with the reduction of growth plate length. Genes related with extracellular matrix in chondrocyte-specific Mob1 deleted cells were downregulated in vitro. These results indicate that Hippo pathway plays a critical role in the regulation of osteogenesis and chondrogenesis.
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| Free Research Field |
腫瘍学
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