2017 Fiscal Year Final Research Report
Analysis of Japanese encephalitis virus infection in mosquito cells
| Project/Area Number |
15K19084
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KUWATA Ryusei 山口大学, 共同獣医学部, 学術研究員 (00711219)
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| Research Collaborator |
MAEDA Ken 山口大学, 共同獣医学部, 教授 (90284273)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 節足動物媒介感染症 / 蚊 / ウイルス / 細胞 / 受容体 |
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| Outline of Final Research Achievements |
Japanese encephalitis virus (JEV) causes viral encephalitis in Asia, estimating nearly 68000 clinical cases of JE globally each year. JEV is transmitted by mosquitoes, and maintained in a cycle between mosquitoes and vertebrate hosts, such as pigs and birds, in nature. Some of JEV receptor on cell surface has been reported on vertebrate cells, but a little or none on mosquito cells. We have established a new experimental systems to examine the cell factor binding to JEV by using virus-like particles (VLPs). Now we applied the JEV_VLPs systems to elucidate the mechanisms for the JEV infections on mosquito cells.
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| Free Research Field |
公衆衛生
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