2016 Fiscal Year Final Research Report
Regulatory mechanisms of autoimmunity by LAG-3 expressing cells
| Project/Area Number |
15K19132
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OKAZAKI Il-mi 徳島大学, 先端酵素学研究所(プロテオ), 准教授 (50452339)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 抑制性免疫補助受容体 / 単一細胞発現解析 |
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| Outline of Final Research Achievements |
LAG-3 is an immuno-inhibitory receptor that plays a critical role in the prevention of autoimmunity. To understand cell population(s) and their role(s) on which LAG-3 functions in the regulation of autoimmunity, we analyzed LAG-3 expressing CD4 T cells by single-cell gene expression analysis. We found that LAG-3 expressing cells were clustered into distinct cell populations and identified unique cell populations that may function in the suppression of autoimmunity.
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| Free Research Field |
免疫学
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