2017 Fiscal Year Final Research Report
The role of miRNA in airway epitherial cells
| Project/Area Number |
15K19439
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
Igarashi Arisa 国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, (非)研究員 (60572998)
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| Research Collaborator |
OKAMURA Kohji
MATSUDA Akio
MATSUMOTO Kenji
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | microRNA / 上皮細胞 / 喘息 |
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| Outline of Final Research Achievements |
To identify miRNAs that regulate expression of IL-33, an important cytokine gene for asthma development, expression of miRNAs in human airway epithelial cells was investigated. Consequently, although a novel miRNA directly controlling IL-33 expression could not be identified, miR-29 was found to regulate epithelial expression of both soluble ST2 (sST2), a decoy receptor for IL-33, and IFNAR1, a type 1 interferon receptor. Furthermore, I found that miR-29 is produced extracellularly via exosomes secreted by airway epithelial cells.
These results suggest that miR-29 may be involved in the IL-33-dependent molecular mechanisms of asthma development, triggered by respiratory viral infection, via regulation of sST2 and IFNAR1 expression in the airway epithelial cells.
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| Free Research Field |
アレルギー
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