Characterization of the T cell repertoire by deep T cell receptor sequencing in tissues and blood from patients with advanced colorectal cancer treated with cetuximab.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19894
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Yamaguchi University
• Principal Investigator: INOUE Yuka 山口大学, 医学部附属病院, 診療助教(4日/週) (50749835)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 癌免疫学 / 進行大腸癌 / セツキシマブ / TCRレパートリー / TCR-α / TCR-β / 多様性

Outline of Final Research Achievements

We started this study, after approval of IRB (Institutional Review Board). Three cases were enrolled this study by now. During this study period, we published a paper of the study which was the opportunity to start this study. Furthermore, we published a paper and reported about analyzing the T cell repertoire in blood samples and cancer tissues in advanced colorectal cancer patients that had received cancer peptide vaccine and oxaliplatin-based chemotherapy, and investigating the relationship between the TCR diversity and the PFS (progression free survival).

Free Research Field

癌免疫学