Elucidation of autophagy function in stromal during pancreatic carcinogenesis process and development of new pancreatic cancer diagnosis or carcinogenesis prevention strategy.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19895
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: EGUCHI Daiki 九州大学, 医学研究院, 共同研究員 (90726390)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: オートファジー / 癌間質 / 膵臓癌

Outline of Final Research Achievements

Autophagy is involved in the proliferation of pancreatic cancer cells in pancreatic cancer, but reports on the relation between pancreatic stellate cells surrounding pancreatic cancer and autophagy were not reported at the time of this study. Therefore, we aimed to clarify the role of autophagy in pancreatic cancer stroma.
We showed that autophagy of pancreatic stellate cells surrounding pancreatic cancer is activated by immunostaining of human pancreatic cancer section. We also showed that autophagy suppression of pancreatic stellate cells reduces invasive ability of pancreatic cancer cells in vitro and in vivo. Furthermore, we showed that pancreatic stellate cells are activated by enhancing autophagy in normal pancreatic stellate cells. We reported to domestic and international academic societies and English journals.

Free Research Field

医歯薬学