2016 Fiscal Year Final Research Report
Therapeutic effects to neuropathic pain by inhibition of STAT1 phosphorization
| Project/Area Number |
15K20047
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Ehime University |
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Principal Investigator |
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| Research Collaborator |
TANAKA Junya
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | マイクログリア活性化 |
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| Outline of Final Research Achievements |
We investigated the therapeutic effects of Chemical X to nerve injury and neuropathic pain. Chemical X didn't have significant effects to inhibition of STAT1 phosphorization in CCI rats. But PSD95, one of neuronal marker, was significantly increased and microglial activation was significantly suppressed in Chemical X administered group. In spinal cord, activated microglia was observed not only in posterior horn but also in anterior horn. Activated microglia with flattened shape intimately attached to large neurons in anterior horn, while those in the left posterior horn displayed amoeboid-like shape and the attachment to neurons was not apparent. We are continuously investigating therapeutic effects of Chemical X and focusing to the difference of activation of microglia in spinal cord.
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| Free Research Field |
神経免疫
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