2016 Fiscal Year Final Research Report
Examination of PPAR alpha dependent mechanism for diabetic retinopathy
| Project/Area Number |
15K20291
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
shiono akira 聖マリアンナ医科大学, 医学部, 助教 (20737598)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | PPARα / トロンボモジュリン / 糖尿病網膜症 |
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| Outline of Final Research Achievements |
Genome-wide analysis using microarray and Chip-sequence showed that the PPARα activation suppresses the inflammatory genes expression, and increases thrombomodulin expression in vascular endothelial cells. And we showed that thrombomodulin is PPARα directed target gene by Chip-sequence. In vivo study, PPARα ligands suppressed inflammatory genes expression in retina and monocyte adhesion in retinal vessels thrombomodulin dependent manner in streptozotocin induced diabetes mellitus rat. These results suggested the anti-inflammatory effect of PPARα activation through the thrombomodulin expression in retina.
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| Free Research Field |
眼科学
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