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2016 Fiscal Year Final Research Report

Development of niucleic delivery system for targeting primary and metametastatic tumor

Research Project

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Project/Area Number 15K20831
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Physical pharmacy
Biomedical engineering/Biomaterial science and engineering
Research InstitutionHokkaido University

Principal Investigator

SATO Yusuke  北海道大学, 薬学研究院, 助教 (10735624)

Project Period (FY) 2015-04-01 – 2017-03-31
Keywords脂質ナノ粒子 / 核酸送達 / 粒子径 / がん浸透性 / 動態制御
Outline of Final Research Achievements

Limitation of diffusion of lipid nanoparticles (LNP) in tumor tissues is a severe problem for development of tumor-targeted short interfering RNA (siRNA) delivery system. In this research, to solve the problem, I developed a technology for controlling LNP size and elucidated the cause for a reduced efficiency of siRNA delivery, which is accompanied by downsizing of the siRNA-loaded LNPs.

Free Research Field

薬物送達学

URL: 

Published: 2018-03-22  

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